Dynamic changes in rat mesenteric lymph proteins following trauma using label-free mass spectrometry.

ABSTRACT: Early events triggered by posttrauma/hemorrhagic shock currently represent a leading cause of morbidity and mortality in these patients. The causative agents of these events have been associated with increased neutrophil priming secondary to shock-dependent alterations of mesenteric lymph. Previous studies have suggested that unknown soluble components of the postshock mesenteric lymph are main drivers of these events. In the present study, we applied a label-free proteomics approach to further delve into the early proteome changes of the mesenteric lymph in response to hemorrhagic shock. Time-course analyses were performed by sampling the lymph every 30 min after shock up until 3 h (the time window within which a climax in neutrophil priming was observed). There are novel, transient early

SUBMITTER: D'Alessandro A 

PROVIDER: S-EPMC4236249 | biostudies-literature | 2014 Dec

REPOSITORIES: biostudies-literature