Ontology highlight
ABSTRACT:
SUBMITTER: Gao D
PROVIDER: S-EPMC4237931 | biostudies-literature | 2014 Sep
REPOSITORIES: biostudies-literature
Cell 20140904 1
The lack of in vitro prostate cancer models that recapitulate the diversity of human prostate cancer has hampered progress in understanding disease pathogenesis and therapy response. Using a 3D organoid system, we report success in long-term culture of prostate cancer from biopsy specimens and circulating tumor cells. The first seven fully characterized organoid lines recapitulate the molecular diversity of prostate cancer subtypes, including TMPRSS2-ERG fusion, SPOP mutation, SPINK1 overexpress ...[more]