Exploiting Issatchenkia orientalis SD108 for succinic acid production.

ABSTRACT:

Background

Recent advances in synthesizing valuable chemicals such as organic acids from low-cost renewable biomass through microbial fermentation have attracted great attention. However, the toxicity of organic acids presents a key challenge to the development of an economically viable fermentation process. Therefore, a platform organism that not only produces organic acids but also tolerates the associated toxicity is highly desirable.

Results

Here we report the discovery, characterization, and engineering of a yeast strain, Issatchenkia orientalis SD108, that is tolerant to low pH and high concentration of organic acids. This strain demonstrated a higher tolerance compared to I. orientalis ATCC 24210 and Classic Distiller's Turbo yeast. In order to explore SD108 as a pote

SUBMITTER: Xiao H 

PROVIDER: S-EPMC4244060 | biostudies-literature | 2014 Aug

REPOSITORIES: biostudies-literature