Ontology highlight
ABSTRACT:
SUBMITTER: Provost E
PROVIDER: S-EPMC4248247 | biostudies-literature | 2014 Dec
REPOSITORIES: biostudies-literature
Zebrafish 20141201 6
Ribosomal proteins are known to be required for proper assembly of mature ribosomes. Recent studies indicate an additional role for ribosomal proteins as candidate tumor suppressor genes. Pancreatic acinar cells, recently identified as effective cells of origin for pancreatic adenocarcinoma, display especially high-level expression of multiple ribosomal proteins. We, therefore, functionally interrogated the ability of two ribosomal proteins, rpl36 and rpl23a, to alter the response to oncogenic K ...[more]