Characterization of novel markers of senescence and their prognostic potential in cancer.

ABSTRACT: Cellular senescence is a terminal differentiation state that has been proposed to have a role in both tumour suppression and ageing. This view is supported by the fact that accumulation of senescent cells can be observed in response to oncogenic stress as well as a result of normal organismal ageing. Thus, identifying senescent cells in in vivo and in vitro has an important diagnostic and therapeutic potential. The molecular pathways involved in triggering and/or maintaining the senescent phenotype are not fully understood. As a consequence, the markers currently utilized to detect senescent cells are limited and lack specificity. In order to address this issue, we screened for plasma membrane-associated proteins that are preferentially expressed in senescent cells. We identified 107 prote

SUBMITTER: Althubiti M 

PROVIDER: S-EPMC4260747 | biostudies-literature | 2014 Nov

REPOSITORIES: biostudies-literature