MOSBIE: a tool for comparison and analysis of rule-based biochemical models.

ABSTRACT:

Background

Mechanistic models that describe the dynamical behaviors of biochemical systems are common in computational systems biology, especially in the realm of cellular signaling. The development of families of such models, either by a single research group or by different groups working within the same area, presents significant challenges that range from identifying structural similarities and differences between models to understanding how these differences affect system dynamics.

Results

We present the development and features of an interactive model exploration system, MOSBIE, which provides utilities for identifying similarities and differences between models within a family. Models are clustered using a custom similarity metric, and a visual interface is provided t

SUBMITTER: Wenskovitch JE 

PROVIDER: S-EPMC4261755 | biostudies-literature | 2014 Sep

REPOSITORIES: biostudies-literature