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Design and synthesis of novel bis-annulated caged polycycles via ring-closing metathesis: pushpakenediol.

ABSTRACT: Intricate caged molecular frameworks are assembled by an atom economical process via a Diels-Alder (DA) reaction, a Claisen rearrangement, a ring-closing metathesis (RCM) and an alkenyl Grignard addition. The introduction of olefinic moieties in the pentacycloundecane (PCUD) framework at appropriate positions followed by RCM led to the formation of novel heptacyclic cage systems.

SUBMITTER: Kotha S 

PROVIDER: S-EPMC4273234 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature

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Design and synthesis of novel bis-annulated caged polycycles via ring-closing metathesis: pushpakenediol.

Kotha Sambasivarao S   Dipak Mirtunjay Kumar MK  

Beilstein journal of organic chemistry 20141113

Intricate caged molecular frameworks are assembled by an atom economical process via a Diels-Alder (DA) reaction, a Claisen rearrangement, a ring-closing metathesis (RCM) and an alkenyl Grignard addition. The introduction of olefinic moieties in the pentacycloundecane (PCUD) framework at appropriate positions followed by RCM led to the formation of novel heptacyclic cage systems. ...[more]

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