Remodeling in cells from different regions of the reentrant circuit during ventricular tachycardia.

ABSTRACT:

Background

Anisotropic reentrant excitation occurs in the remodeled substrate of the epicardial border zone (EBZ) of the 5-day infarcted canine heart. Reentry is stabilized because of the formation of functional lines of block. We hypothesized that regional differences of ionic currents in cells of the EBZ form these lines of block. Therefore, we first mapped reentrant circuits of sustained tachycardias, then dispersed cells (infarct zone cells, IZs) from the central common pathway of the circuit (IZc) as well as from the other side of the line of block (outer pathway, IZo) for study.

Methods and results

We mapped reentrant circuits in the EBZ of infarcted hearts during sustained ventricular tachycardias (>30 seconds, n=17 episodes, cycle lengths=218+/-7.9 ms). INa density w

SUBMITTER: Baba S 

PROVIDER: S-EPMC4289139 | biostudies-literature | 2005 Oct

REPOSITORIES: biostudies-literature