Genetic association of apolipoprotein E polymorphisms with inflammatory bowel disease.

ABSTRACT:

Aim

To study the association of apolipoprotein E (APOE) polymorphisms with the susceptibility of inflammatory bowel disease (IBD) in Saudi patients.

Methods

APOE genotyping was performed to evaluate the allele and genotype frequencies in 378 Saudi subjects including IBD patients with ulcerative colitis (n = 84) or Crohn's disease (n = 94) and matched controls (n = 200) using polymerase chain reaction and reverse-hybridization techniques.

Results

The frequencies of the APOE ε2 allele and ε2/ε3 and ε2/ε4 genotypes were significantly higher in IBD patients than in controls (P < 0.05), suggesting that the ε2 allele and its heterozygous genotypes may increase the susceptibility to IBD. On the contrary, the frequencies of the ε3 allele and ε3/ε3 genotype were lower in IBD p

SUBMITTER: Al-Meghaiseeb ES 

PROVIDER: S-EPMC4299342 | biostudies-literature | 2015 Jan

REPOSITORIES: biostudies-literature