Lineage-specific biomarkers predict response to FGFR inhibition.
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ABSTRACT:
SUBMITTER: Loch DC
PROVIDER: S-EPMC4300517 | biostudies-literature | 2012 Dec
REPOSITORIES: biostudies-literature
Publications
Lineage-specific biomarkers predict response to FGFR inhibition.
Loch David C DC Pollock Pamela M PM
Cancer discovery 20121201 12
In this issue of Cancer Discovery, Guagnano and colleagues use a large and diverse annotated collection of cancer cell lines, the Cancer Cell Line Encyclopedia, to correlate whole-genome expression and genomic alteration datasets with cell line sensitivity data to the novel pan-fibroblast growth factor receptor (FGFR) inhibitor NVP-BGJ398. Their findings underscore not only the preclinical use of such cell line panels in identifying predictive biomarkers, but also the emergence of the FGFRs as v ...[more]
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