Expression of early growth response factor-1 in rats with cerulein-induced acute pancreatitis and its significance.

ABSTRACT:

Aim

To observe the expressions of early growth response factor-1 (Egr-1) and tissue factor (TF) in rats with cerulein-induced acute pancreatitis and to explore its significance.

Methods

A large dose of cerulein was used to create the experimental acute pancreatitis model in rats. The changes of Egr-1 mRNA and protein in rats were observed during 30 min to 4 h after the treatment and immunohistochemical method was used to observe the localized expression of Egr-1 in tissues. In addition to the mRNA expression of Egr-1 target gene, TF was also observed. A blank control group, and a bombesin-administered group were used for comparison.

Results

After the stimulation of a large dose of cerulein, the rats showed typical inflammatory changes of acute pancreatitis. Thirty min

SUBMITTER: Gong LB 

PROVIDER: S-EPMC4321922 | biostudies-literature | 2005 Aug

REPOSITORIES: biostudies-literature