Human Peripheral CD4(+) Vδ1(+) γδT Cells Can Develop into αβT Cells.

ABSTRACT: The lifelong generation of αβT cells enables us to continuously build immunity against pathogens and malignancies despite the loss of thymic function with age. Homeostatic proliferation of post-thymic naïve and memory T cells and their transition into effector and long-lived memory cells balance the decreasing output of naïve T cells, and recent research suggests that also αβT-cell development independent from the thymus may occur. However, the sites and mechanisms of extrathymic T-cell development are not yet understood in detail. γδT cells represent a small fraction of the overall T-cell pool, and are endowed with tremendous phenotypic and functional plasticity. γδT cells that express the Vδ1 gene segment are a minor population in human peripheral blood but predominate in epithelial (and

SUBMITTER: Ziegler H 

PROVIDER: S-EPMC4329445 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature