Fraction of exhaled nitric oxide values in childhood are associated with 17q11.2-q12 and 17q12-q21 variants.

ABSTRACT:

Background

The fraction of exhaled nitric oxide (Feno) value is a biomarker of eosinophilic airway inflammation and is associated with childhood asthma. Identification of common genetic variants associated with childhood Feno values might help to define biological mechanisms related to specific asthma phenotypes.

Objective

We sought to identify the genetic variants associated with childhood Feno values and their relation with asthma.

Methods

Feno values were measured in children age 5 to 15 years. In 14 genome-wide association studies (N = 8,858), we examined the associations of approximately 2.5 million single nucleotide polymorphisms (SNPs) with Feno values. Subsequently, we assessed whether significant SNPs were expression quantitative trait loci in genome-wide exp

SUBMITTER: van der Valk RJ 

PROVIDER: S-EPMC4334587 | biostudies-literature | 2014 Jul

REPOSITORIES: biostudies-literature