PaCO2 in surfactant, positive pressure, and oxygenation randomised trial (SUPPORT).

ABSTRACT:

Objective

To determine the association of arterial partial pressure of carbon dioxide PaCO2 with severe intraventricular haemorrhage (sIVH), bronchopulmonary dysplasia (BPD), and neurodevelopmental impairment (NDI) at 18-22 months in premature infants.

Design

Secondary exploratory data analysis of Surfactant, Positive Pressure, and Oxygenation Randomised Trial (SUPPORT).

Setting

Multiple referral neonatal intensive care units.

Patients

1316 infants 24 0/7 to 27 6/7 weeks gestation randomised to different oxygenation (SpO2 target 85-89% vs 91-95%) and ventilation strategies.

Main outcome measures

Blood gases from postnatal day 0 to day14 were analysed. Five PaCO2 variables were defined: minimum (Min), maximum (Max), SD, average (time-weighted), and a four

SUBMITTER: Ambalavanan N 

PROVIDER: S-EPMC4336211 | biostudies-literature | 2015 Mar

REPOSITORIES: biostudies-literature