Nuclear envelope lamin-A couples actin dynamics with immunological synapse architecture and T cell activation.

ABSTRACT: In many cell types, nuclear A-type lamins regulate multiple cellular functions, including higher-order genome organization, DNA replication and repair, gene transcription, and signal transduction; however, their role in specialized immune cells remains largely unexplored. We showed that the abundance of A-type lamins was almost negligible in resting naïve T lymphocytes, but was increased upon activation of the T cell receptor (TCR). The increase in lamin-A was an early event that accelerated formation of the immunological synapse between T cells and antigen-presenting cells. Polymerization of F-actin in T cells is a critical step for immunological synapse formation, and lamin-A interacted with the linker of nucleoskeleton and cytoskeleton (LINC) complex to promote F-actin polymerization. W

SUBMITTER: Gonzalez-Granado JM 

PROVIDER: S-EPMC4337980 | biostudies-literature | 2014 Apr

REPOSITORIES: biostudies-literature