Circulating Prostaglandin Biosynthesis in Colorectal Cancer and Potential Clinical Significance.

ABSTRACT:

Background

Colorectal cancer (CRC) represents the third leading cause of cancer-related death in the United States. Lack of reliable biomarkers remains a critical issue for early detection of CRC. In this study, we investigated the potential predictive values of circulating prostaglandin (PG) biosynthesis in CRC risk.

Methods

Profiles of circulating PG biosynthesis and platelet counts were determined in healthy subjects (n = 16), familial adenomatous polyposis (FAP) patients who were classified as regular aspirin users (n = 14) or nonusers (n = 24), and CRC patients with (n = 18) or without FAP history (n = 20). Immunohistochemistry staining was performed on biopsy samples.

Results

Analysis of circulating PG biosynthesis unexpectedly revealed that CRC progression is a

SUBMITTER: Li H 

PROVIDER: S-EPMC4347518 | biostudies-literature | 2015 Feb

REPOSITORIES: biostudies-literature