Ontology highlight
ABSTRACT:
SUBMITTER: Mackley EC
PROVIDER: S-EPMC4354100 | biostudies-literature | 2015 Jan
REPOSITORIES: biostudies-literature
Nature communications 20150109
Presentation of peptide:MHCII by RORγ-expressing group 3 innate lymphoid cells (ILC3s), which are enriched within gut tissue, is required for control of CD4 T-cell responses to commensal bacteria. It is not known whether ILC populations migrate from their mucosal and peripheral sites to local draining secondary lymphoid tissues. Here we demonstrate that ILC3s reside within the interfollicular areas of mucosal draining lymph nodes, forming a distinct microenvironment not observed in peripheral ly ...[more]