Ontology highlight
ABSTRACT:
SUBMITTER: Georgescu W
PROVIDER: S-EPMC4357342 | biostudies-literature | 2008 Feb
REPOSITORIES: biostudies-literature
Georgescu Walter W Jourquin Jerome J Estrada Lourdes L Anderson Alexander R A AR Quaranta Vito V Wikswo John P JP
Lab on a chip 20071221 2
Historically, it has been difficult to generate accurate and reproducible protein gradients for studies of interactions between cells and extracellular matrix. Here we demonstrate a method for rapid patterning of protein gradients using computer-driven hydrodynamic focusing in a simple microfluidic device. In contrast to published work, we are moving the complexity of gradient creation from the microfluidic hardware to dynamic computer control. Using our method, switching from one gradient profi ...[more]