Variation in longevity gene KLOTHO is associated with greater cortical volumes.

ABSTRACT:

Objective

Identifying genetic variation associated with brain structures in aging may elucidate new biologic mechanisms underlying resilience to cognitive decline. We investigated whether carrying one copy of the protective haplotype "KL-VS" in longevity gene KLOTHO (KL) is associated with greater gray matter volume in healthy human aging compared to carrying no copies.

Methods

We performed unbiased whole-brain analysis in cognitively normal older adults from two independent cohorts to assess the relationship between KL-VS and gray matter volume using voxel-based morphometry.

Results

We found that KL-VS heterozygosity was associated with greater volume in right dorsolateral prefrontal cortex (rDLPFC). Because rDLPFC is important for executive function, we analyzed wor

SUBMITTER: Yokoyama JS 

PROVIDER: S-EPMC4369272 | biostudies-literature | 2015 Mar

REPOSITORIES: biostudies-literature