Deleterious effects of endocrine disruptors are corrected in the mammalian germline by epigenome reprogramming.

ABSTRACT:

Background

Exposure to environmental endocrine-disrupting chemicals during pregnancy reportedly causes transgenerationally inherited reproductive defects. We hypothesized that to affect the grandchild, endocrine-disrupting chemicals must alter the epigenome of the germ cells of the in utero-exposed G1 male fetus. Additionally, to affect the great-grandchild, the aberration must persist in the germ cells of the unexposed G2 grandchild.

Results

Here, we treat gestating female mice with vinclozolin, bisphenol A, or di-(2-ethylhexyl)phthalate during the time when global de novo DNA methylation and imprint establishment occurs in the germ cells of the G1 male fetus. We map genome-wide features in purified G1 and G2 prospermatogonia, in order to detect immediate and persistent epi

SUBMITTER: Iqbal K 

PROVIDER: S-EPMC4376074 | biostudies-literature | 2015 Mar

REPOSITORIES: biostudies-literature