Clinical significance of ALDH2 rs671 polymorphism in esophageal cancer: evidence from 31 case-control studies.

ABSTRACT:

Background

Aldehyde dehydrogenase 2 (ALDH2), a critical enzyme for the detoxification of alcohol, is associated with many types of cancers. To verify the relationship of ALDH2 rs671 G>A polymorphism and esophageal cancer (EC), we performed a meta-analysis of a total of 31 published data including 8,510 patients and 16,197 controls.

Methods

The pooled odds ratio (OR) and the 95% confidence interval (CI) were calculated using a fixed or random-effects model. Heterogeneity (PH ), publication bias, and sensitivity analysis were also determined.

Results

Although a protective effort was found in the rs671 homozygote comparison (AA/GG: OR=0.69; 95% CI=0.48-0.98), the heterozygote comparison was apparently associated with the risk of EC, particularly in the Chinese population

SUBMITTER: Zhao T 

PROVIDER: S-EPMC4376259 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature