Serum uric acid concentrations and SLC2A9 genetic variation in Hispanic children: the Viva La Familia Study.

ABSTRACT:

Background

Elevated concentrations of serum uric acid are associated with increased risk of gout and renal and cardiovascular diseases. Genetic studies in adults have consistently identified associations of solute carrier family 2, member 9 (SLC2A9), polymorphisms with variation in serum uric acid. However, it is not known whether the association of serum uric acid with SLC2A9 polymorphisms manifests in children.

Objective

The aim was to investigate whether variation in serum uric acid is under genetic influence and whether the association with SLC2A9 polymorphisms generalizes to Hispanic children of the Viva La Familia Study.

Design

We conducted a genomewide association study with 1.1 million genetic markers in 815 children.

Results

We found serum uric acid to

SUBMITTER: Voruganti VS 

PROVIDER: S-EPMC4381775 | biostudies-literature | 2015 Apr

REPOSITORIES: biostudies-literature