Common genetic variants related to vitamin D status are not associated with esophageal squamous cell carcinoma risk in China.

ABSTRACT:

Background

Few studies have examined the association of common genetic variants related to vitamin D metabolism and signaling to esophageal squamous cell carcinoma (ESCC).

Methods

We evaluated the association between 12 single nucleotide polymorphisms (SNPs) in four genes related to vitamin D levels and ESCC risk using data from a genome-wide association study. Participants were recruited from the Shanxi Upper Gastrointestinal Cancer Genetics Project and the Linxian Nutrition Intervention Trials, and included 1942 ESCC cases and 2111 controls. We used logistic models to estimate odds ratios (ORs) and 95% confidence intervals (CIs) for the SNP associations, after controlling for age and gender.

Results

None of the 12 evaluated SNPs in the four vitamin D-related genes w

SUBMITTER: Wang JB 

PROVIDER: S-EPMC4382354 | biostudies-literature | 2015 Apr

REPOSITORIES: biostudies-literature