Ontology highlight
ABSTRACT:
SUBMITTER: Lu G
PROVIDER: S-EPMC4389243 | biostudies-literature | 2015 Mar
REPOSITORIES: biostudies-literature
Lu Geming G Zhang Ruihua R Geng Shuo S Peng Liang L Jayaraman Padmini P Chen Chun C Xu Feifong F Yang Jianjun J Li Qin Q Zheng Hao H Shen Kimberly K Wang Juan J Liu Xiyu X Wang Weidong W Zheng Zihan Z Qi Chen-Feng CF Si Chuanping C He John Cijiang JC Liu Kebin K Lira Sergio A SA Sikora Andrew G AG Li Liwu L Xiong Huabao H
Nature communications 20150327
Here we show that iNOS-deficient mice display enhanced classically activated M1 macrophage polarization without major effects on alternatively activated M2 macrophages. eNOS and nNOS mutant mice show comparable M1 macrophage polarization compared with wild-type control mice. Addition of N6-(1-iminoethyl)-L-lysine dihydrochloride, an iNOS inhibitor, significantly enhances M1 macrophage polarization while S-nitroso-N-acetylpenicillamine, a NO donor, suppresses M1 macrophage polarization. NO derive ...[more]