Molecular PET Imaging of Cyclophosphamide Induced Apoptosis with 18F-ML-8.

ABSTRACT: In this paper, a novel small-molecular apoptotic PET imaging probe, (18)F-ML-8 with a malonate motif structure, is presented and discussed. After study, the small tracer that belongs to a member of ApoSense family is proved to be capable of imaging merely apoptotic regions in the CTX treated tumor-bearing mice. The experimental result is further confirmed by in vitro cell binding assays and TUNEL staining assay. As a result, (18)F-ML-8 could be used for noninvasive visualization of apoptosis induced by antitumor chemotherapy.

SUBMITTER: Yao S 

PROVIDER: S-EPMC4420799 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature