Dataset Information

Influence of lifestyle on the FAIM2 promoter methylation between obese and lean children: a cohort study.

ABSTRACT:

Objective

An obesity-related gene, Fas apoptotic inhibitory molecule 2 (FAIM2), is regulated by nutritional state and the methylation levels of the FAIM2 promoter are significantly associated with obesity. Lifestyle factors, such as sedentary behaviour and physical activity, might modify epigenetic patterns that have been related to obesity. Whether the molecular mechanisms by which FAIM2 affects obesity are involved in lifestyle is unclear. This study investigates the potential differences of the FAIM2 promoter methylation with sedentary behaviour and physical activity in obese and lean children.

Design

Cohort study.

Setting

Institute of Pediatrics in China.

Participants

59 obese cases and 39 lean controls aged 8-18 years recruited from a cross-sectional survey of children from Beijing in 2013.

Primary and secondary outcome measures

The FAIM2 promoter methylation was quantified using the Sequenom MassARRAY platform. Sedentary behaviour and physical activity were investigated using a questionnaire. The influences of different lifestyles on methylation variations in obese and lean children were examined by multiple linear regression.

Results

The methylation levels at seven CpG sites of the FAIM2 promoter were significantly associated with sedentary behaviour, especially the methylation levels at site -975, site -413, sites -362 and -360, and sites -353 and -349 (p=0.00004, 0.00009, 0.0006 and 0.00005, respectively). There were significant differences between the methylation levels at four CpG sites in obese and lean participants with high or moderate physical activity level <150 min/week.

Conclusions

This study provides the first evidence that there are significant differences in the associations of the FAIM2 promoter methylation with sedentary behaviour and physical activity between obese and lean children. Our results suggest that lifestyle may possibly be mediating the process of the FAIM2 involved in obesity.

SUBMITTER: Wu L

PROVIDER: S-EPMC4420961 | biostudies-literature | 2015 Apr

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Influence of lifestyle on the FAIM2 promoter methylation between obese and lean children: a cohort study.

Wu Lijun L Zhao Xiaoyuan X Shen Yue Y Huang Guimin G Zhang Meixian M Yan Yinkun Y Hou Dongqing D Meng Linghui L Liu Junting J Cheng Hong H Mi Jie J

BMJ open 20150428 4

<h4>Objective</h4>An obesity-related gene, Fas apoptotic inhibitory molecule 2 (FAIM2), is regulated by nutritional state and the methylation levels of the FAIM2 promoter are significantly associated with obesity. Lifestyle factors, such as sedentary behaviour and physical activity, might modify epigenetic patterns that have been related to obesity. Whether the molecular mechanisms by which FAIM2 affects obesity are involved in lifestyle is unclear. This study investigates the potential differen ...[more]

PMID: 25922107

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Dataset Information

Influence of lifestyle on the FAIM2 promoter methylation between obese and lean children: a cohort study.

Objective

Design

Setting

Participants

Primary and secondary outcome measures

Results

Conclusions

Publications

Influence of lifestyle on the FAIM2 promoter methylation between obese and lean children: a cohort study.

Similar Datasets

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