Simultaneous synthesis of treatment effects and mapping to a common scale: an alternative to standardisation.

ABSTRACT:

Objective

Trials often may report several similar outcomes measured on different test instruments. We explored a method for synthesising treatment effect information both within and between trials and for reporting treatment effects on a common scale as an alternative to standardisation

Study design

We applied a procedure that simultaneously estimates a pooled treatment effect and the "mapping" ratios between the treatment effects on test instruments in a connected network. Standardised and non-standardised treatment effects were compared. The methods were illustrated in a dataset of 22 trials of selective serotonin reuptake inhibitors against placebo for social anxiety disorder, each reporting treatment effects on between one and six of a total nine test instruments.

Res

SUBMITTER: Ades AE 

PROVIDER: S-EPMC4433769 | biostudies-literature | 2015 Mar

REPOSITORIES: biostudies-literature