A potent antioxidant small molecule aimed at targeting metal-based oxidative stress in neurodegenerative disorders.

ABSTRACT: Metal-ion misregulation and oxidative stress have been linked to the progressive neurological decline associated with multiple neurodegenerative disorders. Transition metal-mediated oxidation of biomolecules via Fenton chemical reactions plays a role in disease progression. Herein we report the synthesis, characterization and antioxidant activity of 2; a pyclen derivative with enhanced antioxidant character.

SUBMITTER: Lincoln KM 

PROVIDER: S-EPMC4446701 | biostudies-literature | 2013 Apr

REPOSITORIES: biostudies-literature