Small molecule inhibitors of the annexin A2 heterotetramer prevent human papillomavirus type 16 infection.

ABSTRACT:

Objectives

High-risk human papillomavirus (HPV) infection leads to the development of several human cancers that cause significant morbidity and mortality worldwide. HPV type 16 (HPV16) is the most common of the cancer-causing genotypes and gains entry to the basal cells of the epithelium through a non-canonical endocytic pathway that involves the annexin A2/S100A10 heterotetramer (A2t). A2t is composed of two annexin A2 monomers bound to an S100A10 dimer and this interaction is a potential target to block HPV16 infection. Here, recently identified small molecule inhibitors of A2t (A2ti) were investigated for their ability to prevent HPV16 infection in vitro.

Methods

A2ti were added to HeLa cells in increasing concentrations prior to the addition of HPV16. Cytotoxicity was e

SUBMITTER: Woodham AW 

PROVIDER: S-EPMC4447890 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature