Association of THBS1 rs1478605 T>C in 5'-untranslated regions with the development and progression of gastric cancer.

ABSTRACT: Thrombospondin 1 (THBS1) plays an important role in angiogenesis and tumor progression. The aim of the present study was to investigate the effects of single-nucleotide polymorphisms (rs1478605 and rs3743125) in the untranslated regions of the THBS1 gene on the development and progression of gastric cancer. In the case-control study, 275 gastric cancer patients and 275 cancer-free controls were successfully genotyped using polymerase chain reaction-restriction fragment length polymorphism. The data demonstrated that THBS1 rs1478605 genotypic distributions significantly differed between the patient and control groups (P=0.005). Carriers of the CC genotype exhibited a decreased risk of developing gastric cancer compared to the carriers of the CT and TT genotypes [adjusted odd r

SUBMITTER: Hong BB 

PROVIDER: S-EPMC4448071 | biostudies-literature | 2015 Mar

REPOSITORIES: biostudies-literature