Lack of association of DRD3 and CNR1 polymorphisms with premenstrual dysphoric disorders.
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ABSTRACT: Background
Premenstrual dysphoric disorder (PMDD) is a mood disorder characterized with physical and affective symptoms during the luteal phase of susceptible women.Objective
The aim of this study was to investigate the association of Dopamine D3 receptor (DRD3) polymorphism, and Cannabinoid receptor Type 1 (CNR1) polymorphism with PMDD.Materials and methods
Fifty one participants with documented PMDD according to the DSM IV criteria and 51 healthy controls were included in this cross sectional study. Symptom severity was measured with daily self-rating, monthly premenstrual assessment forms and psychiatric interviews. The genotyping of DRD3 receptor and Cannabinoid type 1 receptors were performed using Taqmanfluorogenic assay method.Results
Distribution of DRD3 and CNR1 polymorphism was not different between patients and controls.Conclusion
These findings do not support a major role of DRD3, and CNR1 polymorphisms in contributing to susceptibility to premenstrual dysphoric disorder.
SUBMITTER: Yıldız M
PROVIDER: S-EPMC4475771 | biostudies-literature | 2015 Apr
REPOSITORIES: biostudies-literature
Publications
Lack of association of DRD3 and CNR1 polymorphisms with premenstrual dysphoric disorders.
Yıldız Mesut M Vural Mehmet M Erdal Mehmet Emin ME İzci Ay Özlem Ö Yılmaz Şenay Görücü ŞG Karababa İbrahim Fatih İF Selek Salih S
Iranian journal of reproductive medicine 20150401 4
<h4>Background</h4>Premenstrual dysphoric disorder (PMDD) is a mood disorder characterized with physical and affective symptoms during the luteal phase of susceptible women.<h4>Objective</h4>The aim of this study was to investigate the association of Dopamine D3 receptor (DRD3) polymorphism, and Cannabinoid receptor Type 1 (CNR1) polymorphism with PMDD.<h4>Materials and methods</h4>Fifty one participants with documented PMDD according to the DSM IV criteria and 51 healthy controls were included ...[more]
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