Lack of association of DRD3 and CNR1 polymorphisms with premenstrual dysphoric disorders.

ABSTRACT:

Background

Premenstrual dysphoric disorder (PMDD) is a mood disorder characterized with physical and affective symptoms during the luteal phase of susceptible women.

Objective

The aim of this study was to investigate the association of Dopamine D3 receptor (DRD3) polymorphism, and Cannabinoid receptor Type 1 (CNR1) polymorphism with PMDD.

Materials and methods

Fifty one participants with documented PMDD according to the DSM IV criteria and 51 healthy controls were included in this cross sectional study. Symptom severity was measured with daily self-rating, monthly premenstrual assessment forms and psychiatric interviews. The genotyping of DRD3 receptor and Cannabinoid type 1 receptors were performed using Taqmanfluorogenic assay method.

Results

Distribution of

SUBMITTER: Yıldız M 

PROVIDER: S-EPMC4475771 | biostudies-literature | 2015 Apr

REPOSITORIES: biostudies-literature