The human cardiac and skeletal muscle proteomes defined by transcriptomics and antibody-based profiling.

ABSTRACT:

Background

To understand cardiac and skeletal muscle function, it is important to define and explore their molecular constituents and also to identify similarities and differences in the gene expression in these two different striated muscle tissues. Here, we have investigated the genes and proteins with elevated expression in cardiac and skeletal muscle in relation to all other major human tissues and organs using a global transcriptomics analysis complemented with antibody-based profiling to localize the corresponding proteins on a single cell level.

Results

Our study identified a comprehensive list of genes expressed in cardiac and skeletal muscle. The genes with elevated expression were further stratified according to their global expression pattern across the human body

SUBMITTER: Lindskog C 

PROVIDER: S-EPMC4479346 | biostudies-literature | 2015 Jun

REPOSITORIES: biostudies-literature