Association of endothelial lipase gene-384A/C with coronary artery disease in Han Chinese people.

ABSTRACT:

Objectives

The endothelial lipase gene (LIPG) is one of the important genes in the metabolism of high-density lipoprotein cholesterol (HDL-C) and may be involved in the pathogenesis of coronary artery disease (CAD).

Materials and methods

To investigate the relationship between the common single nucleotide polymorphisms (SNPs) 584C/T (rs2000813) and -384A/C (rs3813082) in the LIPG gene and CAD, allele and genotype frequencies of the two SNPs were analysed in 287 Chinese patients with CAD and 367 controls by the high-resolution melting curve (HRM) method.

Results

For 584C/T, no significant difference in polymorphic distribution was observed between patients and controls. However, the frequencies of allele C (20.2% vs 15%, p=0.013, OR=1.437, 95% CI 1.078 to 1.915) at -38

SUBMITTER: Xie L 

PROVIDER: S-EPMC4486941 | biostudies-literature | 2015 Jun

REPOSITORIES: biostudies-literature