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Circadian genes Per1 and Per2 increase radiosensitivity of glioma in vivo.

ABSTRACT: Per1 and Per2 play a key role in regulating the circadian rhythm in mammals. We report here that although both genes were expressed with a circadian rhythm in glioma and normal brain tissue in rats, their expression profiles differed in the two types of tissue. In addition, high expression of Per1 and Per2 in glioma tissue was associated with increased sensitivity to x-irradiation. No such sensitizing effect was observed in normal tissue. Our results suggest that Per1 and Per2 expression may increase the efficacy of radiotherapy against glioma by promoting apoptosis.

SUBMITTER: Zhanfeng N 

PROVIDER: S-EPMC4496409 | biostudies-literature | 2015 Apr

REPOSITORIES: biostudies-literature

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Circadian genes Per1 and Per2 increase radiosensitivity of glioma in vivo.

Zhanfeng Niu N   Yanhui Li L   Zhou Fei F   Shaocai Hao H   Guangxing Li L   Hechun Xia X  

Oncotarget 20150401 12

Per1 and Per2 play a key role in regulating the circadian rhythm in mammals. We report here that although both genes were expressed with a circadian rhythm in glioma and normal brain tissue in rats, their expression profiles differed in the two types of tissue. In addition, high expression of Per1 and Per2 in glioma tissue was associated with increased sensitivity to x-irradiation. No such sensitizing effect was observed in normal tissue. Our results suggest that Per1 and Per2 expression may inc  ...[more]

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