Genetic architecture of natural variation in Drosophila melanogaster aggressive behavior.

ABSTRACT: Aggression is an evolutionarily conserved complex behavior essential for survival and the organization of social hierarchies. With the exception of genetic variants associated with bioamine signaling, which have been implicated in aggression in many species, the genetic basis of natural variation in aggression is largely unknown. Drosophila melanogaster is a favorable model system for exploring the genetic basis of natural variation in aggression. Here, we performed genome-wide association analyses using the inbred, sequenced lines of the Drosophila melanogaster Genetic Reference Panel (DGRP) and replicate advanced intercross populations derived from the most and least aggressive DGRP lines. We identified genes that have been previously implicated in aggressive behavior as well as many nov

SUBMITTER: Shorter J 

PROVIDER: S-EPMC4500262 | biostudies-literature | 2015 Jul

REPOSITORIES: biostudies-literature