Engineering Escherichia coli coculture systems for the production of biochemical products.
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ABSTRACT:
SUBMITTER: Zhang H
PROVIDER: S-EPMC4500268 | biostudies-literature | 2015 Jul
REPOSITORIES: biostudies-literature
Publications
Engineering Escherichia coli coculture systems for the production of biochemical products.
Zhang Haoran H Pereira Brian B Li Zhengjun Z Stephanopoulos Gregory G
Proceedings of the National Academy of Sciences of the United States of America 20150625 27
Engineering microbial consortia to express complex biosynthetic pathways efficiently for the production of valuable compounds is a promising approach for metabolic engineering and synthetic biology. Here, we report the design, optimization, and scale-up of an Escherichia coli-E. coli coculture that successfully overcomes fundamental microbial production limitations, such as high-level intermediate secretion and low-efficiency sugar mixture utilization. For the production of the important chemica ...[more]
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