Methodology and effects of repeated intranasal delivery of DNSP-11 in a rat model of Parkinson's disease.

ABSTRACT:

Background

To circumvent the challenges associated with delivering large compounds directly to the brain for the treatment of Parkinson's disease (PD), non-invasive procedures utilizing smaller molecules with protective and/or restorative actions on dopaminergic neurons are needed.

New method

We developed a methodology for evaluating the effects of a synthetic neuroactive peptide, DNSP-11, on the nigrostriatal system using repeated intranasal delivery in both normal and a unilateral 6-hydroxydopamine (6-OHDA) lesion rat model of PD.

Results

Normal rats repeatedly administered varying doses of DNSP-11 intranasally for 3 weeks exhibited a significant increase in dopamine (DA) turnover in both the striatum and substantia nigra (SN) at 300μg, suggestive of a stimulative e

SUBMITTER: Stenslik MJ 

PROVIDER: S-EPMC4500736 | biostudies-literature | 2015 Aug

REPOSITORIES: biostudies-literature