MiR-30e* is an independent subtype-specific prognostic marker in breast cancer.

ABSTRACT:

Background

Breast cancer clinical outcome is affected by tumor molecular features, and the identification of subtype-specific prognostic biomarkers is relevant for breast cancer translational research. Gene expression signatures proved to be able to complement prognostic information provided by classical clinico-pathological features. Recently, microRNAs (miRNAs) have been causally linked to tumorigenesis and cancer progression and have been associated with patient outcome, also in breast cancer.

Methods

MicroRNAs associated with the development of distant metastasis were identified in a cohort of 92 ESR1+/ERBB2- lymph node-negative breast cancers from patients not receiving adjuvant treatment. Results were confirmed and further investigated in a total of 1246 miRNA and gene

SUBMITTER: D'Aiuto F 

PROVIDER: S-EPMC4506390 | biostudies-literature | 2015 Jul

REPOSITORIES: biostudies-literature