Buprenorphine treatment of opioid-dependent pregnant women: a comprehensive review.

ABSTRACT:

Aims

This paper reviews the published literature regarding outcomes following maternal treatment with buprenorphine in five areas: maternal efficacy, fetal effects, neonatal effects, effects on breast milk and longer-term developmental effects.

Methods

Within each outcome area, findings are summarized first for the three randomized clinical trials and then for the 44 non-randomized studies (i.e. prospective studies, case reports and series and retrospective chart reviews), only 28 of which involve independent samples.

Results

Results indicate that maternal treatment with buprenorphine has comparable efficacy to methadone, although difficulties may exist with current buprenorphine induction methods. The available fetal data suggest buprenorphine results in less physiol

SUBMITTER: Jones HE 

PROVIDER: S-EPMC4506646 | biostudies-literature | 2012 Nov

REPOSITORIES: biostudies-literature