Ontology highlight
ABSTRACT:
SUBMITTER: Ozmadenci D
PROVIDER: S-EPMC4510695 | biostudies-literature | 2015 Jul
REPOSITORIES: biostudies-literature
Nature communications 20150708
The generation of induced pluripotent stem (iPS) cells holds great promise in regenerative medicine. The use of the transcription factors Oct4, Sox2, Klf4 and c-Myc for reprogramming is extensively documented, but comparatively little is known about soluble molecules promoting reprogramming. Here we identify the secreted cue Netrin-1 and its receptor DCC, described for their respective survival/death functions in normal and oncogenic contexts, as reprogramming modulators. In various somatic cell ...[more]