Association between interleukin 8-251 T/A and +781 C/T polymorphisms and glioma risk.

ABSTRACT:

Background

Gliomas are aggressive tumors of the central nervous system that rely on production of growth factors for tumor progression. Interleukin 8 (IL-8) is up-regulated in gliomas to promote angiogenesis and proliferation. The aim of this study was to evaluate the association of the IL-8 -251 T/A and +781 C/T polymorphisms and glioma risk.

Methods

We enrolled 300 glioma patients and 300 age- and gender-matched healthy controls. A prospective hospital-based case-control design and logistic regression analysis were utilized. The IL-8 gene polymorphisms were genotyped by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP).

Results

Glioma patients had a significantly higher frequency of IL-8 -251 AA genotype [odds ratio (OR) =1.91, 95% confid

SUBMITTER: Liu H 

PROVIDER: S-EPMC4528780 | biostudies-literature | 2015 Aug

REPOSITORIES: biostudies-literature