Comprehensive, Integrative Genomic Analysis of Diffuse Lower-Grade Gliomas.

ABSTRACT:

Background

Diffuse low-grade and intermediate-grade gliomas (which together make up the lower-grade gliomas, World Health Organization grades II and III) have highly variable clinical behavior that is not adequately predicted on the basis of histologic class. Some are indolent; others quickly progress to glioblastoma. The uncertainty is compounded by interobserver variability in histologic diagnosis. Mutations in IDH, TP53, and ATRX and codeletion of chromosome arms 1p and 19q (1p/19q codeletion) have been implicated as clinically relevant markers of lower-grade gliomas.

Methods

We performed genomewide analyses of 293 lower-grade gliomas from adults, incorporating exome sequence, DNA copy number, DNA methylation, messenger RNA expression, microRNA expression, and targeted pr

SUBMITTER: Cancer Genome Atlas Research Network 

PROVIDER: S-EPMC4530011 | biostudies-literature | 2015 Jun

REPOSITORIES: biostudies-literature