Estimating PMTCT's Impact on Heterosexual HIV Transmission: A Mathematical Modeling Analysis.

ABSTRACT:

Introduction

Prevention of mother-to-child HIV transmission (PMTCT) strategies include combined short-course antiretrovirals during pregnancy (Option A), triple-drug antiretroviral treament (ART) during pregnancy and breastfeeding (Option B), or lifelong ART (Option B+). The WHO also recommends ART for HIV treatment and prevention of sexual transmission of HIV. The impact of PMTCT strategies on prevention of sexual HIV transmission of HIV is not known. We estimated the population-level impact of PMTCT interventions on heterosexual HIV transmission in southwestern Uganda and KwaZulu-Natal, South Africa, two regions with different HIV prevalence and fertility rates.

Materials and methods

We constructed and validated dynamic, stochastic, network-based HIV transmission models fo

SUBMITTER: Khanna AS 

PROVIDER: S-EPMC4532442 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature