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Linking two DNA duplexes with a rigid linker for DNA nanotechnology.

ABSTRACT: DNA has recently emerged as a promising material for the construction of nanosized architectures. Chemically modified DNA has been suggested to be an important component of such architectural building blocks. We have designed and synthesized a novel H-shaped DNA oligonucleotide dimer that is cross-linked with a structurally rigid linker composed of phenylene and ethynylene groups. A rotatable DNA unit was constructed through the self-assembly of this H-shaped DNA component and two complementary DNA oligonucleotides. In addition to the rotatable unit, a locked DNA unit containing two H-shaped DNA components was also constructed. As an example of an extended locked structure, a hexagonal DNA origami dimer and oligomer were constructed by using H-shaped DNA as linkers.

SUBMITTER: Tashiro R

PROVIDER: S-EPMC4538841 | biostudies-literature | 2015 Aug

REPOSITORIES: biostudies-literature

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Linking two DNA duplexes with a rigid linker for DNA nanotechnology.

Tashiro Ryu R Iwamoto Masahiro M Morinaga Hironobu H Emura Tomoko T Hidaka Kumi K Endo Masayuki M Sugiyama Hiroshi H

Nucleic acids research 20150630 14

DNA has recently emerged as a promising material for the construction of nanosized architectures. Chemically modified DNA has been suggested to be an important component of such architectural building blocks. We have designed and synthesized a novel H-shaped DNA oligonucleotide dimer that is cross-linked with a structurally rigid linker composed of phenylene and ethynylene groups. A rotatable DNA unit was constructed through the self-assembly of this H-shaped DNA component and two complementary ...[more]

PMID: 26130712

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