Whole-genome sequencing reveals the effect of vaccination on the evolution of Bordetella pertussis.

ABSTRACT: Herd immunity can potentially induce a change of circulating viruses. However, it remains largely unknown that how bacterial pathogens adapt to vaccination. In this study, Bordetella pertussis, the causative agent of whooping cough, was selected as an example to explore possible effect of vaccination on the bacterial pathogen. We sequenced and analysed the complete genomes of 40 B. pertussis strains from Finland and China, as well as 11 previously sequenced strains from the Netherlands, where different vaccination strategies have been used over the past 50 years. The results showed that the molecular clock moved at different rates in these countries and in distinct periods, which suggested that evolution of the B. pertussis population was closely associated with the country vaccination cov

SUBMITTER: Xu Y 

PROVIDER: S-EPMC4539551 | biostudies-literature | 2015 Aug

REPOSITORIES: biostudies-literature