MYB rearrangement and clinicopathologic characteristics in head and neck adenoid cystic carcinoma.

ABSTRACT: Salivary gland adenoid cystic carcinoma (ACC) is rare, aggressive, and challenging to treat. Many ACCs have a t(6;9) chromosomal translocation resulting in a MYB-NFIB fusion gene, but the clinical significance is unclear. The purposes of this study were to describe the clinicopathologic factors impacting survival and to determine the prevalence and clinical significance of MYB-NFIB fusion.Case series.Medical records of patients treated for ACC of the head and neck from 1974 to 2011 were reviewed and clinicopathologic data recorded. Fluorescence in situ hybridization (FISH) was used to detect MYB rearrangement in archival tumor tissue as a marker of MYB-NFIB fusion.One hundred fifty-eight patients were included, with median follow-up 75.1 months. Median overall survival was 171.5 months (95% confidence interval [CI]?=?131.9-191.6), and median disease-free survival was 112.0 months (95% CI?=?88.7-180.4). Advanced stage was associated with decreased overall survival (adjusted ptrend ?

SUBMITTER: Rettig EM 

PROVIDER: S-EPMC4546892 | biostudies-literature | 2015 Sep

REPOSITORIES: biostudies-literature