Six and 12 Weeks of Caloric Restriction Increases β Cell Function and Lowers Fasting and Postprandial Glucose Concentrations in People with Type 2 Diabetes.

ABSTRACT:

Background

Caloric restriction alone has been shown to improve insulin action and fasting glucose metabolism; however, the mechanism by which this occurs remains uncertain.

Objective

We sought to quantify the effect of caloric restriction on β cell function and glucose metabolism in people with type 2 diabetes.

Methods

Nine subjects (2 men, 7 women) with type 2 diabetes [BMI (in kg/m(2)): 40.6 ± 1.4; age: 58 ± 3 y; glycated hemoglobin: 6.9% ± 0.2%] were studied using a triple-tracer mixed meal after withdrawal of oral diabetes therapy. The oral minimal model was used to measure β cell function. Caloric restriction limited subjects to a pureed diet (<900 kcal/d) for the 12 wk of study. The studies were repeated after 6 and 12 wk of caloric restriction.

Results

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SUBMITTER: Sathananthan M 

PROVIDER: S-EPMC4548160 | biostudies-literature | 2015 Sep

REPOSITORIES: biostudies-literature