Effect of apolipoprotein E (APO E) polymorphism on leptin in Alzheimer's disease.

ABSTRACT:

Background

Leptin, a 16 kDa peptide hormone synthesized and secreted specifically from white adipose cells protects neurons against amyloid β-induced toxicity, by increasing Apolipoprotein E (APO E)-dependent uptake of β amyloid into the cells, thereby, protect individuals from developing Alzheimer's disease (AD). The APO E ε4 allele is a known genetic risk factor for AD by accelerating onset. It is estimated that the lifetime risk of developing AD increases to 29% for carriers with one ε4 allele and 9% for those with no ε4 allele.

Objectives

To determine the levels of serum leptin, cholesterol, low density lipoprotein (LDL-C), and high density lipoprotein (HDL-C) in the diagnosed cases of AD and the association of them with cognitive decline and Apolipoprotein E (APO E) gen

SUBMITTER: Agarwal R 

PROVIDER: S-EPMC4564468 | biostudies-literature | 2015 Jul-Sep

REPOSITORIES: biostudies-literature