Antibody-Dependent Cellular Inhibition Is Associated With Reduced Risk Against Febrile Malaria in a Longitudinal Cohort Study Involving Ghanaian Children.
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ABSTRACT:
SUBMITTER: Tiendrebeogo RW
PROVIDER: S-EPMC4567085 | biostudies-literature | 2015 Apr
REPOSITORIES: biostudies-literature
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Antibody-Dependent Cellular Inhibition Is Associated With Reduced Risk Against Febrile Malaria in a Longitudinal Cohort Study Involving Ghanaian Children.
Tiendrebeogo Regis W RW Adu Bright B Singh Susheel K SK Singh Susheel K SK Dziegiel Morten H MH Nébié Issa I Sirima Sodiomon B SB Christiansen Michael M Dodoo Daniel D Theisen Michael M
Open forum infectious diseases 20150410 2
The antibody-dependent respiratory burst and opsonic phagocytosis assays have been associated with protection against malaria; however, other mechanisms may also be involved. The antibody-dependent cellular inhibition (ADCI) assay is yet to be correlated with protection in longitudinal cohort studies (LCS). We investigated the relationship between ADCI activity of immunoglobulin G before malaria season and risk of malaria in a LCS involving Ghanaian children. High ADCI activity was significantly ...[more]
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