Synthetic Studies to Lyngbouilloside: A Phosphate Tether-Mediated Synthesis of the Macrolactone Core.

ABSTRACT: A concise synthetic pathway to the originally assigned structure of lyngbouilloside macrolactone (3) is reported. The core macrocycle 3 was synthesized via a phosphate tether-mediated, one-pot, sequential RCM/CM/chemoselective hydrogenation reaction, Roskamp homologation, and a high yielding Boeckman acylketene cyclization.

SUBMITTER: Chegondi R 

PROVIDER: S-EPMC4572573 | biostudies-literature | 2015 Jun

REPOSITORIES: biostudies-literature